Oxidative Phosphorylation in Mitochondria from Aged Rats
نویسندگان
چکیده
منابع مشابه
The efficiency of oxidative phosphorylation in mitochondria from diabetic rats.
Considerable evidence has accumulated which indicates that insulin plays an important rBle in phosphate metabolism (1, 2). A number of workers have postulated that insulin has as its primary function the regulation of the efficiency of oxidative phosphorylation. In attempts to test this hypothesis, Goranson and Erulkar (3) observed that tissues from alloxan-diabetic rats appear to fix phosphate...
متن کاملImpaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats.
Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes in adulthood. We have developed an IUGR model in the rat whereby the animals develop diabetes between 3 and 6 mo of age that is associated with insulin resistance. Alterations in hepatic glucose metabolism are known to contribute to the hyperglycemia of diabetes; however, the mechanisms underlying this ...
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In recent years there has been an increasing tendency to determine the intracellular action of hormones. Many hormones are known to have an effect on carbohydrate metabolism in general and on carbohydrate oxidation and adenosine triphosphate synthesis in particular. Previous work in this laboratory has shown that the efficiency of oxidative phosphorylation is depressed in insulin-deficient anim...
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Studies by many investigators (1, 2) have shown that the rate of succinate oxidation in various tissues was depressed by thyroidectomy and elevated by thyroid treatment of hypothyroid and normal animals. More recent work (3) has indicated that much of the increased oxidative activity may be due to higher levels of the oxidative enzymes after the administration of thyroid hormones, in vivo. Rece...
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It has been known for many years that a number of different nutritional deficiencies lower the efficiency of food utilization. For example, riboflavin-deficient rats consume 15 to ‘20% more calories than are required to maintain control animals at the same weight (1). The lowered efficiency of food utilization in riboflavin deficiency has been attributed in part to incomplete oxidation of nutri...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)70315-3